Comparatively, the median and interquartile range of direct renin concentration in 33 non-pregnant patients with confirmed aldosteronism were 3.8 mU/L and 2.9 to 7.5 mU/L, compared to the mean and interquartile range of 20.3 mU/L and 10.3 to 33 mU/L in 77 non-pregnant patients with essential hypertension [26]. This evidence concerns the gene REN and essential hypertension.