In our present investigation, our data showed that dysregulated levels of HDACs such as HDAC2 (basophils, lymphocytes, monocytes, neutrophils, HDL, and LDL), HDAC3 (HB, PCV, neutrophils, HDL, and LDL), HDAC9 (TLC, basophils, lymphocytes, monocytes, neutrophils, HDL, and LDL), HDAC1 (basophils and neutrophils), HDAC6 (SBP, DBP, basophils, monocytes, and T. cholesterol), HDAC8 (HDL and LDL), and less known HDAC11 was correlated with the hematological/biochemical parameters (TLC and monocytes) of CAD patients. This evidence concerns the gene HDAC6 and coronary artery disorder.