In our present investigation, our data showed that dysregulated levels of HDACs such as HDAC2 (basophils, lymphocytes, monocytes, neutrophils, HDL, and LDL), HDAC3 (HB, PCV, neutrophils, HDL, and LDL), HDAC9 (TLC, basophils, lymphocytes, monocytes, neutrophils, HDL, and LDL), HDAC1 (basophils and neutrophils), HDAC6 (SBP, DBP, basophils, monocytes, and T. cholesterol), HDAC8 (HDL and LDL), and less known HDAC11 was correlated with the hematological/biochemical parameters (TLC and monocytes) of CAD patients. The gene discussed is HDAC2; the disease is coronary artery disorder.