Paradoxically, the binding of AGEs to RAGE further exacerbates oxidative stress through a series of signaling cascades, and this AGE–RAGE interaction and the ensuing signaling cascade for the release of inflammatory cytokines and nuclear transcription factors are leading causes for the onset of pancreatic cancers in cases of diabetes and obesity. The gene discussed is AGER; the disease is obesity due to melanocortin 4 receptor deficiency.