Multiple studies and meta-analyses, utilizing a wide range of cut off values (0.3–18.7), have failed to show any accurate diagnostic capabilities of CRP to detect MIAC, HCA or neonatal infection, in the setting of women presenting with suspected chorioamnionitis [61,62,63,64,65] or PPROM [60,66,67]. Here, CRP is linked to preterm premature rupture of the membranes.