However, the oncogenic EGFR signaling in lung cancer with EGFR mutations contributed to a non-inflamed tumor immune microenvironment (TIME) characterized by a limited infiltration of CD8+ T cells [36,37,38], a high number of infiltrations of regulatory CD4+ T cells [38], and an increased number of inactivated infiltrated T cells [39]. This evidence concerns the gene CD4 and neoplasm.