In HER-2-upregulated CRC tissues, CD4, CD8, CD19, CD68, CD11b, Ly6G, and CD56 expressions were elevated (0.70 ± 0.37 vs. 0.32 ± 0.17, <i>p</i> = 0.03; 0.22 ± 0.13 vs. 0.09 ± 0.06, <i>p</i> = 0.03; 0.31 ± 0.19 vs. 0.12 ± 0.08, <i>p</i> = 0.02; 1.05 ± 0.62 vs. 0.43 ± 0.21, <i>p</i> < 0.01; 1.34 ± 0.81 vs. 0.53 ± 0.23, <i>p</i> < 0.01; 0.50 ± 0.31 vs. 0.19 ± 0.10, <i>p</i> < 0.01; 1.26 ± 0.74 vs. 0.52 ± 0.24, <i>p</i> < 0.01). The gene discussed is CD68; the disease is colorectal carcinoma.