MMP8 and periodontal disorder: Thus, total MMP-8 containing both latent proMMP-8 and active MMP-8 seems too prone to inaccuracies because of latent proMMP-8 and is not accurate enough for periodontal disease diagnostics, whereas measuring aMMP-8 levels leads to more accurate presentation of the collagenolytic tissue destruction in the clinically active disease sites and progressive lesions (Figure 1).