Furthermore, Paraboschi conducted an investigation to validate the levels of expression of a circRNA originating from a genomic region linked with MS, namely hsa_circ_0043813 originated from the STAT3 (Signal Transducer and Activator of Transcription 3) gene [101]: the activation of STAT3 is mediated by a diverse range of cytokines, which in turn, elicits a multitude of crucial biological activities and it has recently shown to be involved in the control of Th17 cell development, which is known to be a critical factor in the pathogenesis of MS [102]. The gene discussed is STAT3; the disease is myeloid sarcoma.