GSDMB and Autoimmunity: In contrast to PBMCs from healthy people, patients with RRMS showed differential expression of approximately 400 circRNAs in their peripheral blood mononuclear cells (PBMCs), according to the research of Cardamone and colleagues about “alternative splicing” (AS) and, specifically, the detection and description of GSDMB, a 17q12-locus alternatively spliced gene that has been frequently linked to autoimmune disorders and asthma susceptibility and that encodes Gasdermin B, a member of the family of proteins that contain gasdermin domains [121,122,123].