Experiments in mice revealed that stereotactic injection of recombinant IL-6 protein into the right caudate putamen (just below the cortex and adjacent to the lateral ventricle of the brain) increased expression of both Mmp-3 and Mmp-9, as well as proliferation and migration of cerebral endothelial cells, further supporting a model where increased IL-6 may modulate intracerebral hemorrhage [253]. Here, IL6 is linked to intracerebral hemorrhage.