Beyond the high catabolic and biosynthetic importance of TCA, several types of malignancies (Acute myeloid leukemia (AML), glioma, paraganglioma, etc.)bear mutations that lead to the dysregulation of one of three TCA enzymes: isocitrate dehydrogenase (IDH), succinate dehydrogenase (SDH), or fumarate hydratase (FH), which, in turn, promotes the synthesis of oncometabolites and favors tumorigenesis in multiple ways [65]. Here, FH is linked to central nervous system cancer.