c-Abl exhibits a proapoptotic function in neurons exposed to amyloid β [21,22], and it is involved in neurodegeneration in Parkinson’s disease [23,24,25,26,27,28,29,30,31] and Alzheimer’s disease (AD) [32,33,34,35,36], in addition to lysosomal storage disorders [37,38] and amyotrophic lateral sclerosis (ALS) [39,40,41]. This evidence concerns the gene ABL1 and amyotrophic lateral sclerosis.