In this context, the doxycycline-inducible Ft-H overexpression and DFO chelator model systems were used to test the hypothesis that iron availability is critical to maintaining genomic integrity during NSCLC cell growth, as well as a target for sensitizing NSCLC cells to DNA damage repair inhibitors and conventional chemoradiation therapies. Here, FTH1 is linked to non-small cell lung carcinoma.