Necrostatin-1 (Nec-1), an antagonist of RIPK1, has the capacity to hinder TNF-induced sepsis by reducing the levels of circulating proinflammatory cytokines and DAMPs, reversing the increased vascular and intestinal permeability, and inhibiting the activation of the coagulation cascade in vascular endothelial cells [152,153,154]. The gene discussed is RIPK1; the disease is Sepsis.