GCLC and Sepsis: In murine sepsis, zinc was shown to activate the nuclear factor-erythroid 2-related factor 2 (Nrf2) transcription factor, which regulates glutathione peroxidase 2 (GPx2), glutamate-cysteine ligase catalytic subunit (GCLC), thioredoxin reductase 1, members of the glutathione-S-transferase (GST), heme-oxygenase-1 (HO-1), and SOD by binding to the anti-oxidant responsive cis-acting enhancer sequence elements [21].