Necrostatin-1 (Nec-1), an antagonist of RIPK1, has the capacity to hinder TNF-induced sepsis by reducing the levels of circulating proinflammatory cytokines and DAMPs, reversing the increased vascular and intestinal permeability, and inhibiting the activation of the coagulation cascade in vascular endothelial cells [152,153,154]. This evidence concerns the gene PCSK1 and Sepsis.