In sepsis, RIPK1 has dual functions and not only can regulate necroptosis in endothelial cells by the TNF and TLR pathways leading to sepsis-induced organ failure [148], but also activates NF-κB via ubiquitination at different sites, induces inflammation states, stabilizes cell lysosome function, induces autophagic activity, and maintains intracellular homeostasis [149]. Here, TNF is linked to Sepsis.