Notably, SELENBP1 also seems to interact with HIF-1; the mouse homolog of SELENBP1 has been identified as a HIF-1 target gene [49], and SELENBP1 has been shown to negatively regulate the alpha subunit of HIF-1 in LNCaP prostate cancer cells [50]. This evidence concerns the gene SELENBP1 and prostate carcinoma.