Although there are few research studies and experimentation on the systemic procoagulant state caused by central nervous system tumors, these studies suggest that abnormal tumor microcirculation may release activated coagulation factors and procoagulant tissue factor containing microparticles (TF-MPs) into the periphery through a spillover effect, which leads to the activation of coagulation cascade [48]. The gene discussed is TF; the disease is neoplasm.