Although Arg-1 expression levels in paired tumor and plasma samples did not correlate (Figure 3C), 7/7 (100%) patients with high plasma and low tumor Arg-1 had nodal metastases and developed recurrence, while only 5/8 (62.5%) and 1/8 (12.5%) patients with low plasma and high tumor Arg-1 had nodal metastasis and developed recurrence, respectively (Figure 3D). Here, ARG1 is linked to neoplasm.