The endothelial activation and stress index (EASIX) and its derivatives, the modified EASIX (m-EASIX), simplified EASIX (s-EASIX), and the risk stratification algorithm EASIX-ferritin/CRP (EASIX-F(C)) are proposed as easy-to-use clinical tools including markers for endothelial dysfunction to assess the risk of severe CRS and ICANS in patients with r/r LBCL [8,16,17,18]. This evidence concerns the gene CRP and congenital rubella syndrome.