Indeed, despite a small number of cases, we report here a positive correlation between the AIDhigh/RAG2low expression signature and the incidence of adverse events in the CNAneg subtype; patients who relapsed in 71% (5/7) were accompanied by high AID expression when compared to 20% (3/15) of those who remained in CR in the entire B-ALL series (p = 0.03; Table S5A). The gene discussed is AICDA; the disease is acute lymphoblastic leukemia.