RAG2 and acute lymphoblastic leukemia: Although recent studies suggest the involvement of RAG2-mediated aberrant recombinations in the evolution of adult B-ALL: t(9;22)/BCR::ABL1pos and BCR::ABL-like [28,29,30,31]; however, no comprehensive analyses on the expression of both enzymes across different genetic subgroups, in correlation to CNA status and clinical outcome, have been carried out in adult ALL so far.