The revised CNA-risk index was valid for the whole series, but most importantly it stratified the prognosis of the two intermediate subgroups: 29% of NEG and 44% of BCR::ABL1pos ALL were accompanied by bad-CNA, while 41% of NEG and 34% of BCR::ABL1pos were associated with good-CNA profile (Figure 5C–F; Table 4A). This evidence concerns the gene BCR and acute lymphoblastic leukemia.