Therefore, taking into account the data shown above, we could propose a novel combined risk-adapted classification for adult B-ALL: by incorporating the stratification of NEG and BCR::ABL1pos subtypes by secondary CNA into the existing genetic classification based on primary aberrations with well-established prognostic effect (Figure 2C,D and Figure 5C–F) we could further refine prognosis of the entire adult ALL population. Here, BCR is linked to precursor B-cell acute lymphoblastic leukemia.