Although recent studies suggest the involvement of RAG2-mediated aberrant recombinations in the evolution of adult B-ALL: t(9;22)/BCR::ABL1pos and BCR::ABL-like [28,29,30,31]; however, no comprehensive analyses on the expression of both enzymes across different genetic subgroups, in correlation to CNA status and clinical outcome, have been carried out in adult ALL so far. Here, BCR is linked to acute lymphoblastic leukemia.