CRP is produced by the hepatocytes in response to the release of the inflammatory cytokines, e.g., interleukin 6 (IL-6) [10], and high concentration (>10 μg/mL) has been associated with advanced cancer stages, metastasis, and poor prognosis [11] in different cancer types including NSCLC [6,7,12,13,14,15]. This evidence concerns the gene CRP and cancer.