Even though we leveraged baseline IL-6 concentration to inform CRP production, as a significant predictor, the availability of longitudinal IL-6 concentration would have allowed a possible linkage of IL-6 kinetics, as a precursor to CRP production, to the CRP kinetic profile and consequently the possibility for an even earlier prediction of the expected CRP concentration, as previously applied in breast cancer, where IL-6 was found to peak two days before CRP [59]. The gene discussed is IL6; the disease is breast carcinoma.