Many genes associated with the pathogenesis or the metastasis of CRC, e.g., Gbp5 [48], Hif3a [49], Hp [50], Il1f9/Il36g [51], Lrg1 [52], Ups18 [53], as well as markers of poor-prognosis/therapy failure in CRC, e.g., Cd14 [54], Cdc20 [55], Mmp8 [56], or Mmp10 [57] were present among the top most downregulated transcripts in Stat2−/− mice receiving DSS, as compared to WT mice from the DSS model [22]. The gene discussed is IL36G; the disease is colorectal carcinoma.