Whether STAT3 plays a role in this context is not known, but in the present study, the levels of pSTAT3 and STAT3 were found to be increased, although not significantly, in the non-tumor tissue from ApcMin/+ Stat2−/− as compared to the non-tumor tissue from ApcMin/+ WT mice (refer to Supplementary Figure S2E). This evidence concerns the gene STAT3 and neoplasm.