CCND1 and neoplasm: Furthermore, levels of cyclin D1, the downstream target of STAT3 which was upregulated in the tumor vs. non-tumor tissue from ApcMin/+ WT as compared with ApcMin/+ Stat2−/− mice (refer to Figure 2E,F), were upregulated in ApcMin/+ WT as compared with ApcMin/+ Stat2−/− tumoroids, strengthening the idea of an epithelial cell-specific contribution of STAT2 in the proliferation of ApcMin/+ tumor cells (Figure 3F).