In this reported case-control genetic association study, we aimed to determine the role of selected SNPs of the CCL2 (rs4586 (903 T>C)), as well as CCL5 (rs2107538 (−403 G>A) and rs2280789 (351 A>G)), CXCL8 (IL8, rs2227532 (−845 T>C) and −738 T>A), and CXCR2 (rs1126580 (1440 G>A)) genes, in the onset and progression of endometrial cancer. This evidence concerns the gene CCL5 and endometrial cancer.