The expression of hormone receptors (HRs) in several tumor types (84 PDX in total) had an impact on total engraftment rate: 57.9% (11/19) of HR-negative models grew, vs. 15.4% (10/65) of HR-positive models (p = 0.0001) (Figure 3E). The gene discussed is NR4A1; the disease is neoplasm.