TP53 and breast cancer: A cross-sectional study that looked at 78 Arab women diagnosed with BC at MD Anderson Cancer Center between January 2010 and December 2018 and who underwent standardized hotspot mutation testing using 46- or 50-gene multiplexes, identified five somatic mutations that were most expressed in these patients: TP53 (23.1%) and PIK3CA (15.4%), followed by PTEN, APC, and KIT (7.7% each).