A study from Oman observed a statistically significant relationship between high elastosis and ER positivity (p = 0.015) and HER2-status (p = 0.045) in 80 female patients who were not treated with neoadjuvant therapy from 2009 to 2019, suggesting that elastosis may be used as a surrogate marker for ER positivity and HER2 negativity in BC [59]. This evidence concerns the gene ESR1 and breast cancer.