Hypermethylation of tumor suppressor genes and silencing in NSCLC influence various biological processes, including cell cycle control (p16), DNA repair (MGMT), apoptosis (DAPK), RAS (RASSF1A) and Wnt (APC) signaling, and invasion suppression (CDH13 and TIMP3) (Table 1). Here, MGMT is linked to non-small cell lung carcinoma.