Additionally, FHIT deletions (Fragile Histidine Triad Diadenosine Triphosphatase) or hypermethylation are observed in from 40% to 70% of NSCLC cases and from 50% to 80% of SCLC cases, underscoring their significance in lung cancer progression. The gene discussed is FHIT; the disease is small cell lung carcinoma.