EGFR and non-small cell lung carcinoma: Panobinostat (LBH589), effectively inhibited the proliferation of NSCLC cell lines A549, Calu-1, H226, H460, H838, and SKMES-1 at IC50 concentrations ranging from 4 to 31 nmol/L through pleiotropic mechanisms that included crosstalk with EGFR signal transduction cascades.