Patel et al. combined whole-genome sequencing and transcriptome analysis and suggested the classification of meningiomas into three major types: type A includes missense mutations in TRAF7, KLF4, and AKT1 and has minimal chromosomal alterations [42], similar to previous findings in benign meningiomas [40]; type B includes NF2-deficient non-aggressive meningiomas; and type C includes more aggressive meningiomas, which have a significant chromosomal instability and chromosomal gains and losses, most commonly losses of both chr22q and chr1p [42]. The gene discussed is KLF4; the disease is meningioma.