The effect of the tumor to CAFs ratio on the morphology of three-dimensional organoids that form in 3D monocultures and cocultures of UT-SCC-24B and UT-SCC-42B tumor cells with hTERT-immortalized and GFP-labeled CAFs after 5 days of seeding is represented in Figure 2. The gene discussed is TBX1; the disease is neoplasm.