Here, we performed a comprehensive bioinformatics analysis of multiple datasets derived from CRC patients and showed that elevated expression of <i>NID1</i> and the genes <i>ITGA3</i>, <i>ITGB1</i>, and <i>ITGAV,</i> which encode NID1 receptors, is associated with poor prognosis and advanced tumor stage. Here, ITGA3 is linked to neoplasm.