After correction for covariates (age, sex, APOE ε4 status), brain tau and amyloid accumulation, astrogliosis and increased sTREM2 levels were associated with 14-3-3 \documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$$\upzeta /\updelta$$\end{document}ζ/δ in T-N- and across the whole AD continuum. The gene discussed is APOE; the disease is Alzheimer disease.