SNAP25 and Alzheimer disease: For example, increased CSF levels of the synaptosomal-associated protein 25 kDa (SNAP25) were observed in predementia and dementia phases of AD [12, 13] 14-3-3 \documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$$\upzeta$$\end{document}ζ is a synaptic protein that recently became an attractive biomarker for testing hypotheses related to early synaptic damage in AD.