When looking across the whole AD continuum (Fig. 4G) GFAP (st. est. = 0.25, P = 0.02) and brain tau load (st. est. = 0.33, P = 0.006) in addition to sTREM2 (st. est. = 0.28, P = 0.001) were significantly mediating synaptic damage. This evidence concerns the gene MAPT and Alzheimer disease.