In order to decrease intracellular PSMC5 protein levels, we performed intracerebroventricular (i.c.v.)infection with a lentivirus carrying shRNA PSMC5 in the mice, which decreased PSMC5 protein levels in the absence (Fig. 2E) or presence of LPS stimulation (Fig. 2F) in the brain tissues. The gene discussed is PSMC5; the disease is infection.