The signaling networks downstream of GPR65 have been implicated in many pathophysiological processes including tumor, immune-related diseases and inflammation through Gαs/cyclic AMP/protein kinase A/cAMP-responsive-element-binding protein (Gαs/cAMP/PKA/CREB) and Gαq/phospholipase C beta/protein kinase C (Gαq/PLC-β/PKC) pathways in response to extracellular stimuli [10–12]. Here, GNAQ is linked to neoplasm.