The results of MTT assay, Wound-healing assay and transwell invasion assay showed that CXCL12 significantly promoted the proliferation, migration and invasion abilities of bladder cancer, and its antagonist AMD3100 was effective in reversing this supportive effect (Fig. 3F-H; Figure S2B-D). The gene discussed is CXCL12; the disease is urinary bladder carcinoma.