Elevated levels of IL-6 (> 25.20 pg/mL) are an independent risk factor for acute exacerbation (AE-IPF) (odds ratio [OR] 1.014, p = 0.036) and mortality (OR 1.007, p = 0.018) in patients with interstitial lung diseases [72]. This evidence concerns the gene IL6 and idiopathic pulmonary fibrosis.