MCM5 and hepatocellular carcinoma: A PPI network based on the intersection genes was constructed (Fig. 7), predicting a gene cluster encoding nine transcriptional factors (AURKB, E2F1, HDAC2, MCM2, MCM3, MCM5, MCM7, PTTG1, and RBL1) that were positively regulated by FOXM1, promoting the cell cycle signaling pathway in HCC.