A PPI network based on the intersection genes was constructed (Fig. 7), predicting a gene cluster encoding nine transcriptional factors (AURKB, E2F1, HDAC2, MCM2, MCM3, MCM5, MCM7, PTTG1, and RBL1) that were positively regulated by FOXM1, promoting the cell cycle signaling pathway in HCC. The gene discussed is E2F1; the disease is hepatocellular carcinoma.