Colchicine reduced mRNA and protein expression of MMP2 in vitro [5], mitigated mRNA expression of MMP-3, MMP-9, and MMP-10 in aortas of mice [23] and abolished the relative mRNA expression of MMP-9 in infarct area of myocardium after myocardial infarction in mice [27]. This evidence concerns the gene MMP10 and myocardial infarction.