The “GSVA” algorithm analysis demonstrated that most of the pathways were mainly enriched in Cluster-C1 (Fig. 3M) and associated with immune system diseases, including asthma, systemic lupus erythematosus, and autoimmune thyroid disease, and Cluster-C1 was also significantly associated with immunoregulating pathways such as T-cell receptor signaling pathway, natural killer cell-mediated cytotoxicity, and JAK-STAT signaling pathway. This evidence concerns the gene SOAT1 and autoimmune thyroid disease.