More specifically, considering that GCAP1 is the major regulator of GC1 in human photoreceptors and that an increasing number of point mutations in its gene are associated with autosomal dominant COD or CORD, the development of novel biological therapies targeting this protein may help to restore the dysregulation of second messenger homeostasis in IRDs, ultimately slowing or blocking cell death. The gene discussed is GUCA1A; the disease is respiratory distress syndrome in premature infants.