The changes in amino acids at codons 47, 72, and 107 do carry phenotypic associations (apoptosis and ferroptosis, binding affinity of the p53 protein to MDM2 ubiquitin ligase regulating p53 protein levels, SH3 protein binding affinities, metabolic differences) that have an impact on the frequencies of cancers [19, 22]. Here, MDM2 is linked to cancer.