This explanation of how combined SNPs and haplotypes can regulate MDM-2 binding to p53, which in turn can regulate p53 levels and activities, which in turn can regulate the selection pressure for TP53 spontaneous mutations in a cell (mutation incidence), and even the age of onset of a tumor initiated by a TP53 mutation, is a reasonable way to understand the phenotypes discussed in this manuscript. Here, MDM2 is linked to neoplasm.