TP53 and Li-Fraumeni syndrome: Supporting this hypothesis, Brazilian carriers of germline TP53 mutations (at risk for Li-Fraumeni Syndrome, a familial predisposition to multiple early cancers) have an accelerated or a delayed age of onset of first cancers depending upon the TP53 alleles p.R72P, Pin2 (G/C) and Pin3 (A-1 or A-2) present in each patient (see Fig. 3) which together can affect the age of a first cancer [31, 32].