IRF3 and infection: Infection of wild type (WT) A549 cells with Sendai virus (SeV) or Zika virus (ZIKV) resulted in robust IFN-I (IFNB1) and IFN-III (IFNL1) transcription and activation of both IRF3-dependent (ISG54) [21] and NF-κB-dependent (NFKBIA) [22] genes (Fig. 1).