ICOS and melanoma: Innate immunity-linked genes (2’-5’-oligoadenylate Synthase Like (OASL)), absent in melanoma 2 (AIM2) and adaptive immunity-linked genes (CD1c molecule, CD207 molecule), co-stimulatory signal during T-cell activation (inducible T-cell co-stimulatory (ICOS)), T-cell chemotaxis (CXCL11), TNF receptor superfamily member (TNFRSF18) involved in leukocyte migration, B-cell proliferation genes (GRB2-binding adapter protein) and genes associated with phagocytosis (carcinoembryonic antigen-related cell adhesion molecule 4 (CEACAM4)) were unique to the IL-1β CD4+ group (Fig. 6e).