MYBPC3 and hypertrophic cardiomyopathy: The functional significance of myosin filament-based regulation for the normal performance of the heart is further underlined by the fact that about 50% of patients suffering from inheritable Hypertrophic Cardiomyopathy (HCM) carry mutations in the genes encoding for either cardiac myosin (MYH7) or cardiac myosin binding protein-C (MYBPC3)17.