The GSEA analysis (Supplementary Table 3) showed that high NPC2 expression was significant associated (P < 0.05) with asthma (Fig. 7A), cytokine-cytokine receptor interaction (Fig. 7B), drug metabolism other enzymes (Fig. 7C), natural killer cell mediated cytotoxicity (Fig. 7D), primary bile acid biosynthesis (Fig. 7E), and systemic lupus erythematosus (Fig. 7F). The gene discussed is NPC2; the disease is asthma.