NPC2 and systemic lupus erythematosus: The GSEA analysis (Supplementary Table 3) showed that high NPC2 expression was significant associated (P < 0.05) with asthma (Fig. 7A), cytokine-cytokine receptor interaction (Fig. 7B), drug metabolism other enzymes (Fig. 7C), natural killer cell mediated cytotoxicity (Fig. 7D), primary bile acid biosynthesis (Fig. 7E), and systemic lupus erythematosus (Fig. 7F).