NPC2 and neoplasm: By univariate and multivariate analysis (Supplementary Figure 3A–B), the age [hazard ratio (HR): 1.825, 95% confidence interval (CI): 1.122–2.967, P = 0.015], stage (HR: 1.320, 95% CI: 1.049–1.661, P = 0.018), radiation therapy (HR: 0.471, 95% CI: 0.318–0.699, P < 0.001), residual tumor (HR: 1.695, 95% CI: 1.290–2.227, P < 0.001), and NPC2 expression (HR: 1.664, 95% CI: 1.190–2.327, P = 0.003) showed independent prognostic value for OS.