PTEN and cancer: Intriguingly, more granular analysis of the relationship between PTEN and other driver mutations in MT-L tumors (Fig. 5c) indicates that the mutual exclusion between PTEN and TP53 is driven entirely by the interaction of TP53 mutations and PTEN LoF mutations; in contrast, TP53 deletions tend to co-occur with PTEN deletions and other alterations.