For instance, in clear cell renal cell carcinoma (ccRCC), miR-184-5p is reported with downregulation in A-498 and 786-O cell lines and its overexpression showed a tumor suppressor role suppressing the proliferation, and invasion and induction of apoptosis by directly targeting the NUS1 dehydrodolichyl diphosphate synthase subunit (NUS1) [157]. This evidence concerns the gene NUS1 and nonpapillary renal cell carcinoma.