Runx2 mutation in Cleidocranial dysplasia (CCD) patient DFSCs impaired matrix remodeling and osteoclast induction in patient DFSCs, which may cause delayed tooth eruption.120,121 But cellular senescence in the dental follicles was reduced in CCD patients compared to healthy controls. The gene discussed is RUNX2; the disease is cleidocranial dysplasia 1.