Moreover, using multiple HCC preclinical models and an ex vivo tumor fragment platform, we dissect the mechanisms by which LDRT sensitizes DPVB by enlarging intratumoral stem-like CD8+ Tpex, which are recruited from the draining lymph nodes (dLNs) into the tumor through the CXCL10/CXCR3 axis. Here, CD8A is linked to hepatocellular carcinoma.