Last but not least, the effector and cytolysis-related genes (Tnf, Gzmb, Ifnγ) were higher in CD8_Tef from tumors with LR-DPVB than in those with DPVB, which strongly supported that the tumor-rejecting CD8+ Tex with effector function and cytolytic capacity was mainly contributed by the CD8_Tef subset (Fig. 3h). The gene discussed is TNF; the disease is neoplasm.