CD8A and hepatocellular carcinoma: Multiplex immunohistochemistry (mIHC) showed that HCC patients with a T + A response presented higher infiltration of stem-like CD8+ Tpex in tumor tissue, while the T + A nonresponse indicated the opposite, which suggested that the intratumoral stem-like CD8+ Tpex infiltration may be a predictor to distinguish patients who are appropriate for T + A treatment.