Comprehensive analysis of exhausted CD8_T cell (including CD8_Tpex, CD8_Tef, and CD8_Tex_term) from LR-DPVB-treated DEN + CCI4 HCC tumors revealed a significant enrichment of CD8_Tef compared to tumors treated with DPVB (Supplementary Fig. 6g). Here, CD8A is linked to hepatocellular carcinoma.