Mouse models bearing either a HepG2 (WT) or MDA-MB-231 (MT) tumor were firstly intratumorally injected with InCasorND4 or InCasorND4-2-MT, which were used to detect the wild type ND4 gene or 12084 C > T mutation (Fig. 6a). The gene discussed is MT-ND4; the disease is neoplasm.