ZEB2+ memory CD4+ T cells from malaria-patients responded to a mixture of the four P. falciparum Ag and CSP alone (~35% CD25+OX40+, ~16% CD25+4-1BB+) while control Ag (i.e., the Exo protein A (EPA) and the P. pastoris (Pp) Pfs25M) stimulation failed to induce any significant upregulation of these activation marker (Fig. 7B and Supplementary Fig. 6B). The gene discussed is TIMP1; the disease is malaria.