ZEB2+ memory CD4+ T cells from malaria-patients responded to a mixture of the four P. falciparum Ag and CSP alone (~35% CD25+OX40+, ~16% CD25+4-1BB+) while control Ag (i.e., the Exo protein A (EPA) and the P. pastoris (Pp) Pfs25M) stimulation failed to induce any significant upregulation of these activation marker (Fig. 7B and Supplementary Fig. 6B). This evidence concerns the gene TNFRSF4 and malaria.