PRDX3 and cancer: Peroxiredoxin 3, suggested to protect cells against apoptosis caused by oxidative stress in hypoxia48, Protein disulfide isomerase family A members 4 and 6, suggested to contribute to avoidance of cell death pathways in some tumours and activation of Wnt signalling49,50, also show increased intensity in voxels further away from vessels, indicating the presence of a cancer proteo-phenotype within the tumour tissue and in dependency of oxygen/nutrient availability in otherwise homogeneous tissue.