Genetic knockdown screening libraries revealed that in the 15% of cancers with MTAP loss, enhanced dependence is conferred on methylthioadenosine transferase 2 alpha (MAT2a, EC:2.5.1.6) and protein arginine methyltransferase 5 (PRMT5, EC:2.1.1.320) (2, 3, 4). Here, MAT2A is linked to cancer.