Additionally, mice with transgenic Tst overexpression in mature adipocytes, showed resistance against HFD-induced obesity and exhibited higher protein expression of mitochondrial superoxide dismutase 2 (SOD2) and higher mRNA levels of peroxiredoxin 3 (Prdx3) compared to control mice, while cytosolic superoxide dismutase 1 (SOD1) remained unchanged [29]. The gene discussed is SOD2; the disease is obesity due to melanocortin 4 receptor deficiency.